Saturday, 23 October 2010

How the herpes Simplex Virus Uses MicroRNA to Hide Out in Cells



Researchers at the University of Pennysylvanis School of Medicine have discovered part of the reason why cold sores, caused by a herpes virus, come back again and again. The study points to a small RNA molecule, called a microRNA (miRNA) as the culprit that keeps the virus-infected cell alive. These findings could one day lead to a new way to fight the virus and offers the first target for intervention in the latent infection.

It was found that the herpes simples virus 1 produces the miRNA molecule. This miRNA is encoded bythe Latency-Associated Transcript gene (LAT) in the viral genome and works through a process called RNA interference to prevent normal cell death or apoptosis.

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